Steven F Maier Selected Research

Toll-Like Receptor 4

1/2021	Experimental autoimmune encephalopathy (EAE)-induced hippocampal neuroinflammation and memory deficits are prevented with the non-opioid TLR2/TLR4 antagonist (+)-naltrexone.
1/2019	Repeated Morphine Prolongs Postoperative Pain in Male Rats.
1/2019	Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell.
1/2017	Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.
4/2015	Opioid-induced central immune signaling: implications for opioid analgesia.
2/2015	Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain.
1/2015	Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4.
4/2014	Systemic administration of propentofylline, ibudilast, and (+)-naltrexone each reverses mechanical allodynia in a novel rat model of central neuropathic pain.
5/2013	Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain.
10/2012	Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats.

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Steven F Maier Research Topics

Disease

56	Pain (Aches) 10/2021 - 01/2003
54	Hyperalgesia 01/2022 - 12/2001
35	Neuralgia (Stump Neuralgia) 10/2022 - 02/2003
18	Shock 01/2021 - 01/2002
17	Infections 05/2018 - 02/2005
16	Inflammation (Inflammations) 01/2021 - 01/2004
11	Neuroinflammatory Diseases 10/2021 - 10/2011
6	Chronic Pain 11/2019 - 03/2005
4	Peripheral Nerve Injuries 01/2022 - 11/2008
4	Memory Disorders (Memory Loss) 01/2021 - 10/2004
4	Wounds and Injuries (Trauma) 01/2017 - 11/2012
4	Fever (Fevers) 10/2011 - 02/2003
4	Bacterial Infections (Bacterial Infection) 08/2011 - 04/2008
4	Opioid-Related Disorders (Opiate Addiction) 01/2010 - 02/2007
3	Contusions 01/2019 - 01/2017
3	Migraine Disorders (Migraine) 01/2017 - 01/2012
3	Escherichia coli Infections 01/2015 - 02/2010
3	AIDS-Related Complex (ARC) 08/2012 - 01/2010
3	Respiratory Insufficiency (Respiratory Failure) 01/2010 - 11/2008
2	Postoperative Cognitive Complications 01/2021 - 10/2012
2	Brain Diseases (Brain Disorder) 01/2021 - 05/2015
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021 - 01/2017
2	Hypersensitivity (Allergy) 11/2019 - 03/2015
2	Obesity 10/2017 - 11/2014
2	Mood Disorders (Mood Disorder) 01/2017 - 11/2003
2	Substance-Related Disorders (Drug Abuse) 01/2015 - 06/2011
2	Peripheral Nervous System Diseases (PNS Diseases) 11/2012 - 07/2007
2	Cognitive Dysfunction 06/2012 - 08/2011

Drug/Important Bio-Agent (IBA)

49	CytokinesIBA 01/2022 - 01/2003
22	Morphine (MS Contin)FDA LinkGeneric 01/2022 - 01/2002
18	Opioid Analgesics (Opioids)IBA 01/2021 - 12/2005
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2005
14	Toll-Like Receptor 4IBA 01/2021 - 07/2008
13	Interleukin-1 (Interleukin 1)IBA 08/2017 - 02/2003
11	Interleukin-10 (Interleukin 10)IBA 01/2019 - 03/2004
9	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021 - 03/2004
9	Brain-Derived Neurotrophic Factor (BDNF)IBA 05/2018 - 10/2004
8	Messenger RNA (mRNA)IBA 01/2021 - 10/2004
8	Interleukin-6 (Interleukin 6)IBA 01/2021 - 02/2003
8	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 02/2003
8	LipopolysaccharidesIBA 02/2015 - 08/2005
8	Interleukin-1beta (Interleukin 1 beta)IBA 11/2014 - 11/2003
8	Pharmaceutical PreparationsIBA 09/2011 - 12/2003
7	Serotonin (5 Hydroxytryptamine)IBA 01/2017 - 02/2002
7	Analgesics (Analgesic Drugs)IBA 09/2011 - 08/2004
6	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 11/2012 - 08/2004
5	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021 - 11/2007
5	Adenosine (Adenocard)FDA LinkGeneric 01/2019 - 11/2009
5	InflammasomesIBA 01/2018 - 08/2015
5	HMGB1 Protein (HMG1)IBA 01/2018 - 12/2003
5	Minocycline (Cyclops)FDA LinkGeneric 01/2017 - 05/2005
5	ChemokinesIBA 01/2017 - 08/2004
5	CorticosteroneIBA 10/2011 - 02/2003
4	Naltrexone (ReVia)FDA LinkGeneric 01/2021 - 07/2008
4	ATL 313IBA 01/2019 - 11/2009
4	salicylhydroxamic acid (SHAM)IBA 01/2019 - 11/2009
4	GlucocorticoidsIBA 11/2018 - 06/2011
4	Dinoprostone (PGE2)FDA Link 01/2017 - 01/2010
3	Neutralizing AntibodiesIBA 01/2019 - 03/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 03/2004
3	BradykininIBA 01/2017 - 01/2010
3	Histamine (Histamine Dihydrochloride)FDA Link 01/2017 - 01/2010
3	ibudilastIBA 01/2017 - 02/2009
3	Ethanol (Ethyl Alcohol)IBA 08/2015 - 05/2013
3	Freund's AdjuvantIBA 02/2014 - 01/2012
3	Formaldehyde (Formol)FDA Link 02/2014 - 10/2010
3	Naloxone (Narcan)FDA LinkGeneric 05/2012 - 07/2008
3	Glycoproteins (Glycoprotein)IBA 01/2010 - 10/2005
2	Superoxides (Superoxide)IBA 10/2022 - 12/2016
2	Pathogen-Associated Molecular Pattern MoleculesIBA 01/2022 - 01/2017
2	MicroRNAs (MicroRNA)IBA 10/2021 - 01/2018
2	Interleukin-17 (Interleukin 17)IBA 01/2021 - 01/2021
2	Opioid Receptors (Opioid Receptor)IBA 01/2021 - 11/2009
2	Toll-Like Receptor 2IBA 01/2021 - 05/2012
2	NLR ProteinsIBA 01/2019 - 01/2016
2	NF-kappa B (NF-kB)IBA 01/2019 - 10/2005
2	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 11/2007
2	LigandsIBA 01/2018 - 01/2017
2	2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosineIBA 01/2018 - 11/2009
2	Neurotransmitter Agents (Neurotransmitter)IBA 12/2016 - 03/2007
2	GlucuronidesIBA 02/2015 - 05/2013
2	morphine-3-glucuronideIBA 02/2015 - 05/2013
2	ethyl glucuronideIBA 02/2015 - 05/2013
2	alpha7 Nicotinic Acetylcholine ReceptorIBA 12/2012 - 08/2010
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 12/2012 - 08/2010
2	Narcotic Antagonists (Opioid Antagonists)IBA 05/2012 - 07/2008
2	Glutamic Acid (Glutamate)FDA Link 09/2011 - 07/2004
2	AntibodiesIBA 08/2010 - 11/2009
2	DNA (Deoxyribonucleic Acid)IBA 07/2007 - 12/2006

Therapy/Procedure

16	Therapeutics 01/2022 - 07/2004
11	Analgesia 12/2016 - 08/2004
10	Spinal Injections 01/2018 - 03/2005
4	Laparotomy 01/2019 - 10/2010
3	Subcutaneous Injections 01/2012 - 03/2004
3	Injections 01/2012 - 12/2003
2	Behavior Control 06/2019 - 09/2012
2	Catheters 01/2017 - 01/2012
2	Pain Management 01/2016 - 04/2015
2	Ligation 10/2013 - 05/2012
2	Operative Surgical Procedures 01/2012 - 01/2004